As one of the highest volume and most experienced transcatheter aortic heart valve replacement (TAVR) programs in the nation, Northwestern Medicine continues to expand its Transcatheter Heart Valve Program by offering a wide array of minimally invasive commercially available therapies and clinical trial options to treat the aortic valve, including TAVR for low-risk patients.

Transcatheter Aortic Heart Valve Therapies: Now Available for Low-Risk Surgical Patients

The Transcatheter Heart Valve Program at Northwestern Medicine began offering transcatheter aortic valve replacement (TAVR) in 2008. For some patients with aortic stenosis, TAVR is an alternative treatment to open heart valve surgery. Since the early days of TAVR, Northwestern Medicine has been a leader in spearheading numerous TAVR clinical trials, helping to expand this therapy in a safe and effective way.

In 2019, the results of two transcatheter aortic valve clinical trials¹ –PARTNER 3 and EVOLUT– suggest that low-risk patients do as well or better with TAVR than with open heart valve surgery to replace a diseased aortic valve. TAVR is not only an option for patients considered medium- or high-risk for open heart valve surgery, but is also an option for younger, healthier, low-risk patients. As one of the top enrolling sites in the United States for the PARTNER 3 clinical trial, we are proud to be leaders in innovating treatment options with easier recoveries and superior results for our patients.

Today, Northwestern Medicine offers a variety of commercially available (FDA approved) TAVR procedures and clinical trial options for the aortic valve, allowing us to tailor treatment precisely to the individual patient’s needs. TAVR therapies are offered at both Northwestern Memorial Hospital and Central DuPage Hospital.

Transcatheter Aortic Valve Commercially Available (FDA Approved) Treatment Options

Transcatheter procedures allow the procedure to be performed while the patient’s heart is still beating, eliminating the need for a “heart bypass” machine and its associated risks. Due to the minimally invasive nature of transcatheter procedures, patients tend to recover faster and experience an improvement in symptoms soon after the procedure is completed. The Transcatheter Heart Valve Program at Northwestern Medicine offers two aortic valve transcatheter treatment options: TAVR and transcatheter aortic valve in valve replacement.

Transcatheter Aortic Valve Replacement (TAVR): A minimally invasive treatment option for patients with aortic valve stenosis. A stenotic aortic valve is narrowed, restricting blood flow from the heart. During TAVR, an interventional cardiologist and/or a cardiac surgeon inserts a catheter (tube) in the body through an artery. The TAVR valve is compressed and advanced by a catheter through an artery until it reaches the diseased aortic valve. A balloon on the catheter expands to secure the TAVR valve within the diseased aortic valve and then the catheter is removed. The secured TAVR valve remains in place pushing the diseased valve out of the way, allowing the TAVR valve to take over the job of regulating blood flow from the heart.

Transcatheter Aortic Valve in Valve Replacement: A minimally invasive TAVR procedure for patients who have had previous open heart valve surgery to replace the aortic valve with a bioprosthetic/tissue valve that is now failing. Instead of replacing the failing aortic valve with another open heart valve surgery, the failing aortic valve is replaced by placing and securing a TAVR valve inside the failing aortic valve.

During aortic valve in valve replacement, an interventional cardiologist and/or a cardiac surgeon inserts a catheter (tube) through an artery in the body. The TAVR valve is compressed and advanced by a catheter through an artery until it reaches the failing aortic valve. A balloon on the catheter expands and secures the TAVR valve within the failing aortic valve. The catheter is then removed and the TAVR valve remains in place pushing the failing aortic valve out of the way, allowing the TAVR valve to take over the job of regulating blood flow from the heart.

Transcatheter Aortic Valve Clinical Trial Options

ALLIANCE Aortic Valve-in-valve: The objective of this non-randomized, multi-center study is to evaluate the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve. The SAPIEN X4 THV is an investigational device and is delivered by a minimally invasive procedure through a small incision in the groin (transfemoral).  Participation requires annual follow-up visits with the study physician 30 days, 6 months and annually through 10 years.
Principal Investigator: S. Chris Malaisrie | ClinicalTrials.gov #: NCT05172973 | NU IRB #: STU00220206

Northwestern Medicine is also among the most experienced programs in the country for transcatheter treatment options for the mitral valve and tricuspid valve.

Meet the Transcatheter Aortic Valve Therapies Team